Description
DSIP (Delta Sleep‑Inducing Peptide) has been investigated for its effects on sleep architecture in controlled human studies. Published clinical trials most commonly used a weight‑based, single daily dose of ~25 nmol/kg (≈21 µg/kg), typically by slow intravenous administration over 1–4 days. The guide below converts that literature dose into practical volumes from a 10 mg (3 mL) vial.
- Most‑studied human dose: ~25 nmol/kg (≈21 µg/kg) per injection
- Frequency: 1× daily; courses of 1–4 consecutive days were commonly explored
- Reconstitution: Use the full 3 mL (max vial capacity) → ~3.33 mg/mL for easy unit counting
- Units math: At 3 mL, each 100‑unit insulin syringe unit ≈ 33 µg DSIP
- Storage: Lyophilized vials frozen; reconstituted solution refrigerated (details below)
Standard / Literature‑Derived Approach (3 mL = 3.33 mg/mL)
Target per‑injection dose: ~25 nmol/kg (≈21 µg/kg). Administer once daily for 1–4 days based on study designs. The table below converts body weight to approximate per‑injection dose and syringe units when the 10 mg vial is reconstituted to 3.0 mL.
| Body Weight | Dosage (per injection) | Units (per injection) (mL) |
|---|---|---|
| 50 kg | ~1,061 µg (1.061 mg) | 32 units (0.32 mL) |
| 60 kg | ~1,273 µg (1.273 mg) | 38 units (0.38 mL) |
| 70 kg | ~1,485 µg (1.485 mg) | 45 units (0.45 mL) |
| 80 kg | ~1,698 µg (1.698 mg) | 51 units (0.51 mL) |
| 90 kg | ~1,910 µg (1.910 mg) | 57 units (0.57 mL) |
| 100 kg | ~2,122 µg (2.122 mg) | 64 units (0.64 mL) |
Notes: Values assume reconstitution to 3.0 mL (10 mg ÷ 3 mL ≈ 3.33 mg/mL). Each 1 unit (on a 100‑unit insulin syringe) = 0.01 mL ≈ 33 µg DSIP. If using a different volume, recalculate proportionally. Literature most often reports slow intravenous administration; routes can vary by study. When injection volumes are small (<10 units), consider 30‑unit or 50‑unit syringes for finer measurement—however, at 3 mL dilution, units per injection are generally ≥10 across common body weights.
Reconstitution (3.0 mL total):
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall to minimize foaming; do not shake.
- Gently swirl until dissolved. Protect from light.
- Refrigerate the reconstituted solution at 2–8 °C. Avoid repeated freeze–thaw.
