Description
Quickstart Highlights
Semax is a synthetic heptapeptide analogue of ACTH(4–10) developed in Russia and studied primarily for cognitive enhancement and neuroprotection. While intranasal administration is most common in clinical literature, subcutaneous injection offers a convenient once‑daily alternative for research purposes. This educational protocol presents a practical SC approach using straightforward reconstitution for accurate insulin‑syringe measurements.
- Reconstitute: Add 3.0 mL bacteriostatic water (max vial capacity) → ~3.33 mg/mL concentration.
- Typical daily range: 300–800 mcg once daily (gradual titration recommended).
- Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U‑100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
Dosing & Reconstitution Guide
Educational guide for reconstitution and weekly dosing
Standard / Gradual Approach (3 mL = ~3.33 mg/mL)
| Week | Daily Dose (mcg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–2 | 300 mcg | 9 units (0.09 mL) |
| Weeks 3–4 | 500 mcg | 15 units (0.15 mL) |
| Weeks 5–6 | 600 mcg | 18 units (0.18 mL) |
| Weeks 7–8 | 800 mcg | 24 units (0.24 mL) |
For ≤10‑unit (≤0.10 mL) administrations, consider 30‑ or 50‑unit insulin syringes for improved readability.
Frequency: Inject once daily subcutaneously. This schedule uses the largest practical dilution (3.0 mL) to ensure per‑injection volumes are accurate and manageable. Most human nootropic studies use intranasal dosing in the range of 400–900 mcg/day divided into multiple administrations; this SC protocol delivers comparable total daily amounts in a single injection for convenience.
Reconstitution Steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake vigorously).
- Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
